There are different filling materials for wrinkles and grooves that can be their own or synthetic and transitory, semi-permanent and permanent, depending on how long they are in the body. Among the most used we must name: natural and synthetic hyaluronic acid, polylactic acid, Acrylic microspheres It is of our preference among the materials of more limited duration, the use of hyaluronic acid (Restylane) and Matrigel. It has different degrees of firmness allowing its use in crow’s feet, frown and worry lines, acne scars, small wrinkles around lips and other facial wrinkles. Profiling and lip augmentation. It is a material that exists naturally between cells. It is considered semi-permanent because it lasts up to one year. Among the most long-lasting fillers, we prefer calcium hydroxyapatite (Radiesse). It can be used to treat people, with wrinkles or folds in the face, who want a lasting treatment, since it has a minimum stay of 3 years at the injection site, although this duration may vary depending on the patients.